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Anthropic de novo protein-binder design evaluation

Designs diverse miniprotein binders against target protein structures in a GPU-equipped research sandbox.

2 models

Higher is better.

  1. 1Claude Opus 5.5Anthropic82.6
  2. 2Claude Sonnet 5.5Anthropic82.3
Higher is better. Bar colour: blue proprietary, orange open weights, green other.

About this benchmark

Metric
Composite structural design score
Tasks
15 protein targets
Authors
Anthropic (2026)

Scores are as reported by model developers or evaluators and may use different settings (for example reasoning effort or tools). Compare with care.