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Anthropic Protein Design evaluation

Generates novel protein sequences under family, topology, globularity, and structural-motif constraints.

3 models

Higher is better.

  1. 1Claude Opus 5.5Anthropic60.2
  2. 2Claude Sonnet 5.5Anthropic51.0
  3. 3Claude Opus 5Anthropic42.5
Higher is better. Bar colour: blue proprietary, orange open weights, green other.

About this benchmark

Metric
Composite score
Tasks
Constrained protein-sequence design tasks
Authors
Anthropic (2026)

Scores are as reported by model developers or evaluators and may use different settings (for example reasoning effort or tools). Compare with care.